Portugal had spent most of the 15th century incrementally pushing exploration further down the West African coast under the sponsorship of Prince Henry the Navigator and his successors, driven by the ambition to find a direct sea route to the lucrative Asian spice trade, currently controlled by an intermediary chain running through Arab traders in the Indian Ocean and Venetian merchants in the Mediterranean, both of whom took substantial cuts that made spices extraordinarily expensive by the time they reached Northern Europe. Bartolomeu Dias's 1488 voyage rounding the Cape of Good Hope proved the African continent could be sailed around, but it was Vasco da Gama, departing Lisbon in July 1497 with four ships, who completed the full route to India.
The voyage was punishing in the extreme. Da Gama's fleet spent months out of sight of any coast crossing the South Atlantic on a wide arc to catch favorable winds, and scurvy — a disease then not understood to be caused by vitamin C deficiency — devastated the crew, killing roughly two-thirds of the men who departed Portugal before the fleet even reached India. Da Gama reached Calicut on India's Malabar coast in May 1498, and although his initial trading efforts were only modestly successful (Indian merchants were unimpressed by the low-value trade goods the Portuguese offered), the voyage proved the sea route was navigable. Da Gama returned to Portugal in 1499 with only two of his original four ships and a fraction of his original crew, but the cargo of spices he did bring back sold for many times the cost of the entire expedition, triggering a massive Portuguese push to establish a permanent, fortified trading and military presence throughout the Indian Ocean over the following decades.