Wilhelm Conrad Röntgen, a German physicist, was experimenting with cathode-ray tubes — glass tubes in which an electric current passes through a near-vacuum, a well-established area of physics research by the 1890s — in November 1895 when he noticed something unexpected: a screen coated with a fluorescent chemical, sitting across his darkened laboratory, glowed faintly whenever his cathode-ray tube was active, even though he had completely enclosed the tube in black cardboard to block any visible light from escaping. Investigating further, Röntgen found that whatever was causing the glow could pass through various materials — including, he soon discovered, human flesh, though it was blocked more effectively by bone and metal.
Within weeks, Röntgen produced what became one of the most famous images in the history of science: an X-ray photograph of his wife Anna Bertha's hand, clearly showing the bones of her fingers and her wedding ring, with the surrounding flesh rendered as a faint shadow. Röntgen published his findings within about six weeks of the initial discovery, in December 1895, and the news spread with remarkable speed — X-ray machines were being used for medical diagnosis within the following year, an unusually fast translation from laboratory discovery to practical clinical application even by the standards of the era's other significant scientific breakthroughs. Röntgen received the first Nobel Prize in Physics in 1901, and specifically donated his prize money to his university, refusing to patent his discovery, which he believed should belong freely to humanity.